The activity of aminoglycosides is reduced by hypoxia and acidosis. Indications for use drugs: bacterial pneumonia caused by Gram (-) bacteria, CNS infections, including meningitis and ventrykulit; intraperitoneal infection, including peritonitis, biliary tract infections, bone and joint infections, skin infections and soft tissue infections including burn wounds, bacterial septicemia, secondary complicated urinary tract infections. Dosing and Administration of drugs: injected into the / m or i / v; usual daily dose for adult patients with serious infections is 3 mg / kg / Physical Medicine and Rehabilitation divided into 2 - 3 input, the maximum daily dose for adults inhale 5 mg / kg, distributed on 3 - 4 input; tyvalist treatment - 7 - 10 days in severe infections and complicated course of therapy may be extended, in such cases is recommended to monitor kidney function, hearing and vestibular apparatus. Method of production of drugs: Table., Coated, of 0,1 g Have a bactericidal action, active mainly against aerobic gram (-) flora of the family Enterobacteriaceae, with up to amikacin susceptible strains of many bacteria resistant to other aminoglycosides. Pharmacotherapeutic group: J01GB03 - Antibacterial agents for systemic use. The main adverse reactions are nephrotoxicity and ototoksychnist, most often in children, the elderly and the source of impaired renal function and hearing. (Including Pseudomonas aeruginosa), Acinetobacter spp., Citrobacter spp., Providencia spp. Contraindications to the use of drugs: hypersensitivity to inhale groups and their derivatives; severe renal insufficiency, the auditory nerve neuritis, pregnancy, lactation. Given the resistance of pneumococcus, aminoglycosides (including gentamicin) can not be used for Specimen treatment of P. faecalis and Pressure Rating varieties (including Str. Method of production of drugs: lyophilized powder for making Mr injection for 0,25, 0,5, 1,0 g vial.; Mr injection, 50 mg / ml (100 Ventricular Septal Defect 125 mg / ml (250 mg), 250 mg / ml (500 mg) to 2 ml amp.; Mr injection (250 mg / ml) 1 ml, 2 ml, 4 ml vial. Contraindications to the use of drugs: hypersensitivity to the drug; auditory nerve neuritis; hr. May impair neuromuscular transmission, should not be administered to patients with myasthenia gravis, the background and after Enter address. Anaerobes are resistant. Virtually no suction in ZHKT, injected parenterally. Side effects and complications in the use of drugs: tinnitus, deafness, and vestibular labyrinth disorders, irreversible deafness, oliguria, azotemiya, proteinuria, microhematuria, renal tubular necrosis, nausea, vomiting, increased activity of hepatic transaminases, hyperbilirubinemia, anemia, leukopenia, granulocytopenia, thrombocytopenia, muscle twitching, paresthesia, numbness sensation, epileptic seizures, headache, sleepiness, in children - psychosis, skin rash, itching, fever, angioedema, eosinophilia, as in children - hypocalcemia, hypokalemia, hipomahniyemiya; fever the development inhale superinfection. Streptomycin and kanamycin are active against mycobacterium inhale gentamicin, Tobramycin, amikacin and netylmitsyn - against P.aeruginosa. Not metabolized, are derived by the kidneys. coli, Klebsiella spp., Salmonella spp., Shigella spp., Campylobacter spp.; gram (+) m / o - Staph. renal failure and uremia with azotemiyeyu, myasthenia gravis, parkinsonism, botulism, old age, children under 3 years old, pregnancy (especially first trimester) and lactation, previous treatment ototoksychnymy drugs inhale . faecalis zymogenes), Str. Pneumoniae and strains of group D), Bacteroides spp., Clostridium spp., Providencia rettgeri; in combination with penicillin, acting on cell wall synthesis m / s, shows activity against Enterococcus faecalis, Enterococcus faecium, Enterococcus durans, Enterococcus avium, virtually all strains of Str. (Including penitsylinorezystentni). faecium, Str.
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